AICAR and nicotinamide treatment synergistically augment the proliferation and attenuate senescence-associated changes in mesenchymal stromal cells

Abstract Background Mesenchymal stromal cell (MSC) stemness capacity diminishes over prolonged in vitro culture, which negatively affects their application in regenerative medicine. To slow down the senescence of MSCs, here, we have evaluated the in vitro effects of 5-aminoimidazole-4-carboxamide ri...

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Bibliografische Detailangaben

Hauptverfasser:	Mohammadhossein Khorraminejad-Shirazi, Mahsa Sani, Tahereh Talaei-Khozani, Mohammadreza Dorvash, Malihe Mirzaei, Mohammad Ali Faghihi, Ahmad Monabati, Armin Attar
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2020-02-01
Schriftenreihe:	Stem Cell Research & Therapy
Schlagworte:	mTOR AMPK SIRT1 Autophagy Senescence AICAR
Online-Zugang:	https://doi.org/10.1186/s13287-020-1565-6
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