Non-viral in vivo cytidine base editing in hepatocytes using focused ultrasound targeted microbubbles

CRISPR-Cas9-based genome editing technologies, such as base editing, have the potential for clinical translation, but delivering nucleic acids into target cells in vivo is a major obstacle. Viral vectors are widely used but come with safety concerns, while current non-viral methods are limited by lo...

Popoln opis

Bibliografske podrobnosti

Principais autores:	Cynthia D. Anderson, Jennifer Ataam Arthur, Yuan Zhang, Nike Bharucha, Ioannis Karakikes, Ralph V. Shohet
Format:	Artigo
Jezik:	Inglês
Izdano:	Elsevier 2023-09-01
Serija:	Molecular Therapy: Nucleic Acids
Teme:	MT: Delivery strategies base editing hepatocytes focused ultrasound microbubbles ultrasound targeted microbubble destruction
Online dostop:	http://www.sciencedirect.com/science/article/pii/S2162253123002056
Oznake:	Označite Brez oznak, prvi označite!