Non-viral in vivo cytidine base editing in hepatocytes using focused ultrasound targeted microbubbles
CRISPR-Cas9-based genome editing technologies, such as base editing, have the potential for clinical translation, but delivering nucleic acids into target cells in vivo is a major obstacle. Viral vectors are widely used but come with safety concerns, while current non-viral methods are limited by lo...
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| Главные авторы: | , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Elsevier
2023-09-01
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| Серии: | Molecular Therapy: Nucleic Acids |
| Предметы: | |
| Online-ссылка: | http://www.sciencedirect.com/science/article/pii/S2162253123002056 |
| Метки: |
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