Non-viral in vivo cytidine base editing in hepatocytes using focused ultrasound targeted microbubbles
CRISPR-Cas9-based genome editing technologies, such as base editing, have the potential for clinical translation, but delivering nucleic acids into target cells in vivo is a major obstacle. Viral vectors are widely used but come with safety concerns, while current non-viral methods are limited by lo...
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| Principais autores: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Elsevier
2023-09-01
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| coleção: | Molecular Therapy: Nucleic Acids |
| Assuntos: | |
| Acesso em linha: | http://www.sciencedirect.com/science/article/pii/S2162253123002056 |
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