NLRP3 activation induces BBB disruption and neutrophil infiltration via CXCR2 signaling in the mouse brain

Abstract NLRP3 is an intracellular sensor molecule that affects neutrophil functionality and infiltration in brain disorders such as experimental autoimmune encephalomyelitis (EAE). However, the detailed molecular mechanisms underlying the role of NLRP3 in these processes remain unknown. We found th...

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Detalhes bibliográficos

Principais autores:	Jaeho Lee, Wooyoung Cho, Je-Wook Yu, Young-Min Hyun
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2025-05-01
coleção:	Journal of Neuroinflammation
Assuntos:	Neutrophils Experimental autoimmune encephalomyelitis (EAE) NLR family pyrin domain-containing 3 protein (NLRP3) CXCR2 Blood-brain barrier (BBB)
Acesso em linha:	https://doi.org/10.1186/s12974-025-03468-6
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