Epithelial NLRP3 drives silica-induced lung injury and fibrosis through IL-18 and pro-fibrotic neutrophil recruitment
Abstract Background Silicosis is a progressive inflammatory and fibrotic lung disease with no effective treatments beyond symptom management. While global NLRP3 inflammasome deficiency attenuates silica-induced pathology, myeloid-specific Nlrp3 deletion provides no protection, suggesting that other...
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| Auteurs principaux: | , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
BMC
2026-05-01
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| Collection: | Particle and Fibre Toxicology |
| Sujets: | |
| Accès en ligne: | https://doi.org/10.1186/s12989-026-00682-9 |
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