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Single cell RNA-seq reveals cellular and transcriptional heterogeneity in the splenic CD11b+Ly6Chigh monocyte population expanded in sepsis-surviving mice

Abstract Background Sepsis survivors exhibit immune dysregulation that contributes to poor long-term outcomes. Phenotypic and functional alterations within the myeloid compartment are believed to be a contributing factor. Here we dissect the cellular and transcriptional heterogeneity of splenic CD11...

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Huvudupphov: Haruki Watanabe, Minakshi Rana, Myoungsun Son, Pui Yan Chiu, Yurong Fei-Bloom, Kwangmin Choi, Betty Diamond, Barbara Sherry
Materialtyp: Artigo
Språk:Inglês
Utgiven: BMC 2024-11-01
Serie:Molecular Medicine
Ämnen:
Sepsis
CLP
CD11b+Ly6Chigh
Phagocytosis
Glycolysis
scRNA-seq
Länkar:https://doi.org/10.1186/s10020-024-00970-0
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