S100A8/A9 increases the mobilization of pro-inflammatory Ly6Chigh monocytes to the synovium during experimental osteoarthritis

Abstract Background Monocytes are dominant cells present within the inflamed synovium during osteoarthritis (OA). In mice, two functionally distinct monocyte subsets are described: pro-inflammatory Ly6Chigh and patrolling Ly6Clow monocytes. Alarmins S100A8/A9 locally released by the synovium during...

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Autori principali:	Niels A. J. Cremers, Martijn H. J. van den Bosch, Stephanie van Dalen, Irene Di Ceglie, Giuliana Ascone, Fons van de Loo, Marije Koenders, Peter van der Kraan, Annet Sloetjes, Thomas Vogl, Johannes Roth, Edwin J. W. Geven, Arjen B. Blom, Peter L. E. M. van Lent
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2017-09-01
Serie:	Arthritis Research & Therapy
Soggetti:	S100 Mobilization Ly6C high/low monocytes Systemic effects Collagenase-induced osteoarthritis
Accesso online:	http://link.springer.com/article/10.1186/s13075-017-1426-6
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