Positive feedback between transcriptional and kinase suppression in nematodes with extraordinary longevity and stress resistance.
Insulin/IGF-1 signaling (IIS) regulates development and metabolism, and modulates aging, of Caenorhabditis elegans. In nematodes, as in mammals, IIS is understood to operate through a kinase-phosphorylation cascade that inactivates the DAF-16/FOXO transcription factor. Situated at the center of this...
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| Principais autores: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Public Library of Science (PLoS)
2009-04-01
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| Serier: | PLoS Genetics |
| Online adgang: | http://europepmc.org/articles/PMC2661368?pdf=render |
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