Extreme depletion of PIP3 accompanies the increased life span and stress tolerance of PI3K-null C. elegans mutants

The regulation of animal longevity shows remarkable plasticity, in that a variety of genetic lesions are able to extend lifespan by as much as tenfold. Such studies have implicated several key signaling pathways that must normally limit longevity, since their disruption prolongs life. Little is kn...

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Manylion Llyfryddiaeth

Prif Awduron:	Puneet eBharill, Srinivas eAyyadevara, Ramani eAlla, Robert Joseph Shmookler Reis
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	Frontiers Media S.A. 2013-03-01
Cyfres:	Frontiers in Genetics
Pynciau:	Insulin Insulin-Like Growth Factor I Oxidative Stress Phosphatidylinositol 3-Kinases Phosphatidylinositols C. elegans
Mynediad Ar-lein:	http://journal.frontiersin.org/Journal/10.3389/fgene.2013.00034/full
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