Extreme depletion of PIP3 accompanies the increased life span and stress tolerance of PI3K-null C. elegans mutants

The regulation of animal longevity shows remarkable plasticity, in that a variety of genetic lesions are able to extend lifespan by as much as tenfold. Such studies have implicated several key signaling pathways that must normally limit longevity, since their disruption prolongs life. Little is kn...

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Bibliografski detalji

Glavni autori:	Puneet eBharill, Srinivas eAyyadevara, Ramani eAlla, Robert Joseph Shmookler Reis
Format:	Artigo
Jezik:	Inglês
Izdano:	Frontiers Media S.A. 2013-03-01
Serija:	Frontiers in Genetics
Teme:	Insulin Insulin-Like Growth Factor I Oxidative Stress Phosphatidylinositol 3-Kinases Phosphatidylinositols C. elegans
Online pristup:	http://journal.frontiersin.org/Journal/10.3389/fgene.2013.00034/full
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