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A narrow quantitative trait locus in C. elegans coordinately affects longevity, thermotolerance, and resistance to paraquat

By linkage mapping of quantitative trait loci, we previously identified at least 11 natural genetic variants that significantly modulate C. elegans lifespan, many of which would have eluded discovery by knockdown or mutation screens. A region on chromosome IV between markers stP13 and stP35 had str...

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Hlavní autoři: Anthony eVertino, Srinivas eAyyadevara, John Joseph Thaden, Robert Joseph Shmookler Reis
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2011-09-01
Edice:Frontiers in Genetics
Témata:
Longevity
Oxidative Stress
C. elegans
Lifespan
linkage mapping
recombinant congenic lines
On-line přístup:http://journal.frontiersin.org/Journal/10.3389/fgene.2011.00063/full
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