N-Acetylneuraminate Pyruvate Lyase Promotes Cell Adaptation to Glucose Deprivation by Regulating Intracellular ATP Levels

N-acetylneuraminate pyruvate lyase (NPL) is a key enzyme in sialic acid catabolism that links sialylation to cellular metabolism, but its role in cancer cell metabolic adaptation is poorly defined. In particular, it remains unclear whether NPL contributes to ATP maintenance in hepatocellular carcino...

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Detalles Bibliográficos

Principais autores:	Zhijun Fan, Yi Li, Shuting Geng, Yu Si, Yuerong Yang, Huali Yu, Xue Hu, Jianhai Jiang
Formato:	Artigo
Idioma:	Inglês
Publicado:	MDPI AG 2026-05-01
Series:	Current Issues in Molecular Biology
Assuntos:	hepatocellular carcinoma N-acetylneuraminate pyruvate lyase glucose deprivation energy homeostasis molecular docking
Acceso en liña:	https://www.mdpi.com/1467-3045/48/6/569
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