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N-Acetylneuraminate Pyruvate Lyase Promotes Cell Adaptation to Glucose Deprivation by Regulating Intracellular ATP Levels

N-acetylneuraminate pyruvate lyase (NPL) is a key enzyme in sialic acid catabolism that links sialylation to cellular metabolism, but its role in cancer cell metabolic adaptation is poorly defined. In particular, it remains unclear whether NPL contributes to ATP maintenance in hepatocellular carcino...

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Principais autores: Zhijun Fan, Yi Li, Shuting Geng, Yu Si, Yuerong Yang, Huali Yu, Xue Hu, Jianhai Jiang
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2026-05-01
coleção:Current Issues in Molecular Biology
Assuntos:
hepatocellular carcinoma
N-acetylneuraminate pyruvate lyase
glucose deprivation
energy homeostasis
molecular docking
Acesso em linha:https://www.mdpi.com/1467-3045/48/6/569
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