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Evaluation of molecular mechanisms of (Z)-3-(pentadec-10′-enyl)-catechol (litreol) and synthetic derivatives as inhibitors of human leukotriene biosynthesis

5-Lipoxygenase (5-LO) catalyzes the early steps of leukotriene (LT) biosynthesis, making it an attractive target for anti-inflammatory drug development. This study provides a more detailed evaluation of the molecular mechanisms and pharmacological effects of litreol (CI), a natural compound from the...

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Principais autores: Alessia Maria Cossu, Simona Pace, Ferdinando Bruno, Lucia Abbatiello, Carmen Cerchia, Emanuele Falbo, Alejandra Catalina Muñoz Ramírez, Christian Kretzer, Laura Miek, Fabiana Troisi, Jana Gerstmeier, Pasquale Ambrosino, Silvia Zappavigna, Antonio La vecchia, Oliver Werz, Michele Caraglia, Rosanna Filosa
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2025-11-01
coleção:Redox Biology
Assuntos:
Leukotrienes
5-Lipoxygenase
Inflammation
Litreol
Leukocytes
Chronic disease
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2213231725003933
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