Human macrophages differentially produce specific resolvin or leukotriene signals that depend on bacterial pathogenicity

Abstract Proinflammatory eicosanoids (prostaglandins and leukotrienes) and specialized pro-resolving mediators (SPM) are temporally regulated during infections. Here we show that human macrophage phenotypes biosynthesize unique lipid mediator signatures when exposed to pathogenic bacteria. E. coli a...

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Главные авторы:	Oliver Werz, Jana Gerstmeier, Stephania Libreros, Xavier De la Rosa, Markus Werner, Paul C. Norris, Nan Chiang, Charles N. Serhan
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Nature Portfolio 2018-01-01
Серии:	Nature Communications
Online-ссылка:	https://doi.org/10.1038/s41467-017-02538-5
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