A Methodological Approach Using rAAV Vectors Encoding Nanobody-Based Biologics to Evaluate ARTC2.2 and P2X7 In Vivo

On murine T cells, mono-ADP ribosyltransferase ARTC2.2 catalyzes ADP-ribosylation of various surface proteins when nicotinamide adenine dinucleotide (NAD+) is released into the extracellular compartment. Covalent ADP-ribosylation of the P2X7 receptor by ARTC2.2 thereby represents an additional mecha...

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Autores principales:	Henri Gondé, Mélanie Demeules, Romain Hardet, Allan Scarpitta, Marten Junge, Carolina Pinto-Espinoza, Rémi Varin, Friedrich Koch-Nolte, Olivier Boyer, Sahil Adriouch
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Frontiers Media S.A. 2021-08-01
Colección:	Frontiers in Immunology
Materias:	P2X7 (purino) receptor AAV vectors nanobodies (VHH) animal models extracellular ATP (eATP) extracellular NAD+
Acceso en línea:	https://www.frontiersin.org/articles/10.3389/fimmu.2021.704408/full
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