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Administration of an AAV vector coding for a P2X7-blocking nanobody-based biologic ameliorates colitis in mice

Abstract Background The pro-inflammatory ATP-gated P2X7 receptor is widely expressed by immune and non-immune cells. Nanobodies targeting P2X7, with potentiating or antagonistic effects, have been developed. Adeno-associated virus (AAV)-mediated gene transfer represents an efficient approach to achi...

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Principais autores: Catalina Abad, Mélanie Demeules, Charlotte Guillou, Henri Gondé, Rachid Zoubairi, Yossan-Var Tan, Carolina Pinto-Espinoza, Waldemar Schäfer, Anna Marei Mann, Valérie Vouret-Craviari, Friedrich Koch-Nolte, Sahil Adriouch
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2024-01-01
coleção:Journal of Nanobiotechnology
Assuntos:
Adeno-associated virus
Nanobodies (VHH)
P2X7
Animal models
Colitis
Acesso em linha:https://doi.org/10.1186/s12951-023-02285-4
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