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Computational design and engineering of self-assembling multivalent microproteins with therapeutic potential against SARS-CoV-2

Abstract Multivalent drugs targeting homo-oligomeric viral surface proteins, such as the SARS-CoV-2 trimeric spike (S) protein, have the potential to elicit more potent and broad-spectrum therapeutic responses than monovalent drugs by synergistically engaging multiple binding sites on viral targets....

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Principais autores: Qin Qin, Xinyi Jiang, Liyun Huo, Jiaqiang Qian, Hongyuan Yu, Haixia Zhu, Wenhao Du, Yuhui Cao, Xing Zhang, Qiang Huang
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2024-02-01
Serier:Journal of Nanobiotechnology
Fag:
SARS-CoV-2
Protein therapeutics
Microprotein
Nanobody
Computational design
Cryo-EM
Online adgang:https://doi.org/10.1186/s12951-024-02329-3
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