Computational design and engineering of self-assembling multivalent microproteins with therapeutic potential against SARS-CoV-2
Abstract Multivalent drugs targeting homo-oligomeric viral surface proteins, such as the SARS-CoV-2 trimeric spike (S) protein, have the potential to elicit more potent and broad-spectrum therapeutic responses than monovalent drugs by synergistically engaging multiple binding sites on viral targets....
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| Principais autores: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
BMC
2024-02-01
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| Series: | Journal of Nanobiotechnology |
| Assuntos: | |
| Acceso en liña: | https://doi.org/10.1186/s12951-024-02329-3 |
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