Cancer cells with alternative lengthening of telomeres do not display a general hypersensitivity to ATR inhibition
Telomere maintenance is a hallmark of cancer as it provides cancer cells with cellular immortality. A significant fraction of tumors uses the alternative lengthening of telomeres (ALT) pathway to elongate their telomeres and to gain an unlimited proliferation potential. Since the ALT pathway is uniq...
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| Principais autores: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Frontiers Media S.A.
2016-08-01
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| Series: | Frontiers in Oncology |
| Assuntos: | |
| Acceso en liña: | http://journal.frontiersin.org/Journal/10.3389/fonc.2016.00186/full |
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