Cancer cells with alternative lengthening of telomeres do not display a general hypersensitivity to ATR inhibition

Telomere maintenance is a hallmark of cancer as it provides cancer cells with cellular immortality. A significant fraction of tumors uses the alternative lengthening of telomeres (ALT) pathway to elongate their telomeres and to gain an unlimited proliferation potential. Since the ALT pathway is uniq...

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Үндсэн зохиолчид:	Katharina I Deeg, Inn Chung, Caroline Bauer, Karsten Rippe
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	Frontiers Media S.A. 2016-08-01
Цуврал:	Frontiers in Oncology
Нөхцлүүд:	ALT VE-821 Alternative lengthening of telomeres ATR inhibitor ataxia telangiectasia- and RAD3-related (ATR)
Онлайн хандалт:	http://journal.frontiersin.org/Journal/10.3389/fonc.2016.00186/full
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!