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Integrative systems biology identifies SIRT1 as a senescence-related theranostic target in atherosclerosis and poliumoside as a natural activator

BackgroundCellular senescence contributes to atherosclerotic plaque progression and instability, yet senescence-related diagnostic biomarkers and actionable targets remain incompletely defined.PurposeTo identify senescence-related diagnostic/therapeutic targets in atherosclerosis using integrative s...

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Principais autores: Xiaolong Wang, Runlu Shi, Chen Ji, Huilin Li, Ziwen Jia, Xin Tian, Xi Xie, Yanping Wang, Qiao-Ping Wang
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2026-05-01
Serier:Frontiers in Pharmacology
Fag:
atherosclerosis
bioinformatics
cellular senescence
natural products
poliumoside
SIRT1
Online adgang:https://www.frontiersin.org/articles/10.3389/fphar.2026.1805938/full
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