Integrative systems biology identifies SIRT1 as a senescence-related theranostic target in atherosclerosis and poliumoside as a natural activator

BackgroundCellular senescence contributes to atherosclerotic plaque progression and instability, yet senescence-related diagnostic biomarkers and actionable targets remain incompletely defined.PurposeTo identify senescence-related diagnostic/therapeutic targets in atherosclerosis using integrative s...

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Detalhes bibliográficos

Principais autores:	Xiaolong Wang, Runlu Shi, Chen Ji, Huilin Li, Ziwen Jia, Xin Tian, Xi Xie, Yanping Wang, Qiao-Ping Wang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2026-05-01
coleção:	Frontiers in Pharmacology
Assuntos:	atherosclerosis bioinformatics cellular senescence natural products poliumoside SIRT1
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fphar.2026.1805938/full
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