Novel driver gene MDC1 confers homologous recombination repair deficiency and genomic instability in chemoresistant relapsing ovarian cancer

Abstract Background Nearly 80% of patients with High grade serous ovarian cancer (HGSOC) will experience recurrence within 5 years, but little is known about the mechanisms that drive this process. Methods In this study we used whole genome sequencing to assess SNV and SV burdens. These were in turn...

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Autores principales:	Michael Diaz, Nicole Gull, Pei-Chen Peng, Kruttika Dabke, Jessica Baker, Jennifer Sun, Juan Alvarado, Benjamin Bastin, Nimisha Mazumdar, Chintda Santiskulvong, Andrew J. Li, Beth Y. Karlan, B. J. Rimel, Sarah J. Parker, Simon A. Gayther, Michelle R. Jones
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	BMC 2026-03-01
Colección:	Journal of Translational Medicine
Materias:	High grade serous ovarian cancer Clonality Structural variants Recurrence Chemoresistance Long read sequencing
Acceso en línea:	https://doi.org/10.1186/s12967-026-07951-3
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