Unbiased combination screening on repurposed drugs reveals synergistic potential of copanlisib and cerivastatin against chemoresistant high-grade serous ovarian cancer

Abstract Introduction High-grade serous ovarian cancers (HGSOCs) are challenging to treat and often resistant to therapy. Despite ongoing therapeutic progress, relapse and poor outcomes remain common among both newly diagnosed and recurrent cases. Systematic high-throughput screening of clinically a...

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Үндсэн зохиолчид:	Yu Sun, Yangyang Wang, Syed Umbreen, Benjamin Pepperrell, Niamh Buckley, Paul Mullan, Ahlam Ali, Fiona Furlong
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	BMC 2025-11-01
Цуврал:	Journal of Ovarian Research
Нөхцлүүд:	Drug screening Drug combinations Chemoresistant high-grade serous ovarian cancer
Онлайн хандалт:	https://doi.org/10.1186/s13048-025-01828-7
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!