Increased CD103−CD8+ TILs with TPEX phenotype replenish anti-tumor T cell pool in mismatch repair-proficient CRC

Abstract While mismatch repair-deficient (dMMR) colorectal cancers (CRCs) exhibit strong immunogenicity and better response to immune checkpoint inhibitors, the more prevalent mismatch repair-proficient (pMMR) CRCs typically show poor T- cell infiltration and inferior outcomes. Profiling the limited...

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Autors principals:	Jinsheng Liu, Jintao Zeng, Ting Zhou, Mi Wu, Xiufang Weng
Format:	Artigo
Idioma:	Inglês
Publicat:	Springer 2025-11-01
Col·lecció:	Cancer Immunology, Immunotherapy
Matèries:	Colorectal cancer CD103−CD8+ T cells TPEX phenotype TCR clonotypes Anti-PD-1treatment
Accés en línia:	https://doi.org/10.1007/s00262-025-04214-w
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