Increased CD103−CD8+ TILs with TPEX phenotype replenish anti-tumor T cell pool in mismatch repair-proficient CRC

Abstract While mismatch repair-deficient (dMMR) colorectal cancers (CRCs) exhibit strong immunogenicity and better response to immune checkpoint inhibitors, the more prevalent mismatch repair-proficient (pMMR) CRCs typically show poor T- cell infiltration and inferior outcomes. Profiling the limited...

Full beskrivning

Bibliografiska uppgifter

Huvudupphov:	Jinsheng Liu, Jintao Zeng, Ting Zhou, Mi Wu, Xiufang Weng
Materialtyp:	Artigo
Språk:	Inglês
Utgiven:	Springer 2025-11-01
Serie:	Cancer Immunology, Immunotherapy
Ämnen:	Colorectal cancer CD103−CD8+ T cells TPEX phenotype TCR clonotypes Anti-PD-1treatment
Länkar:	https://doi.org/10.1007/s00262-025-04214-w
Taggar:	Lägg till en tagg Inga taggar, Lägg till första taggen!