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Increased CD103−CD8+ TILs with TPEX phenotype replenish anti-tumor T cell pool in mismatch repair-proficient CRC

Abstract While mismatch repair-deficient (dMMR) colorectal cancers (CRCs) exhibit strong immunogenicity and better response to immune checkpoint inhibitors, the more prevalent mismatch repair-proficient (pMMR) CRCs typically show poor T- cell infiltration and inferior outcomes. Profiling the limited...

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Principais autores: Jinsheng Liu, Jintao Zeng, Ting Zhou, Mi Wu, Xiufang Weng
Format: Artigo
Sprog:Inglês
Udgivet: Springer 2025-11-01
Serier:Cancer Immunology, Immunotherapy
Fag:
Colorectal cancer
CD103−CD8+ T cells
TPEX phenotype
TCR clonotypes
Anti-PD-1treatment
Online adgang:https://doi.org/10.1007/s00262-025-04214-w
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