Myeloid cell expression of CD200R is modulated in active TB disease and regulates Mycobacterium tuberculosis infection in a biomimetic model

A robust immune response is required for resistance to pulmonary tuberculosis (TB), the primary disease caused by Mycobacterium tuberculosis (Mtb). However, pharmaceutical inhibition of T cell immune checkpoint molecules can result in the rapid development of active disease in latently infected indi...

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Principais autores:	Mohamed Ahmed, Liku B. Tezera, Nicholas Herbert, Mark Chambers, Michaela T. Reichmann, Kievershen Nargan, Henrik Kloverpris, Farina Karim, Mbali Hlatshwayo, Rajhmun Madensein, Munir Habesh, Monjural Hoque, Adrie J.C. Steyn, Paul T. Elkington, Alasdair J. Leslie
Formato:	Artigo
Idioma:	Inglês
Publicado:	Frontiers Media S.A. 2024-04-01
Series:	Frontiers in Immunology
Assuntos:	tuberculosis pulmonary infection immune checkpoint CD200 receptor innate immunity
Acceso en liña:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1360412/full
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