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NAD(H) homeostasis underlies host protection mediated by glycolytic myeloid cells in tuberculosis

Abstract Mycobacterium tuberculosis (Mtb) disrupts glycolytic flux in infected myeloid cells through an unclear mechanism. Flux through the glycolytic pathway in myeloid cells is inextricably linked to the availability of NAD+, which is maintained by NAD+ salvage and lactate metabolism. Using lung t...

Whakaahuatanga katoa

I tiakina i:
Ngā taipitopito rārangi puna kōrero
Ngā kaituhi matua: Hayden T. Pacl, Krishna C. Chinta, Vineel P. Reddy, Sajid Nadeem, Ritesh R. Sevalkar, Kievershen Nargan, Kapongo Lumamba, Threnesan Naidoo, Joel N. Glasgow, Anupam Agarwal, Adrie J. C. Steyn
Hōputu: Artigo
Reo:Inglês
I whakaputaina: Nature Portfolio 2023-09-01
Rangatū:Nature Communications
Urunga tuihono:https://doi.org/10.1038/s41467-023-40545-x
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