NAD(H) homeostasis underlies host protection mediated by glycolytic myeloid cells in tuberculosis

Abstract Mycobacterium tuberculosis (Mtb) disrupts glycolytic flux in infected myeloid cells through an unclear mechanism. Flux through the glycolytic pathway in myeloid cells is inextricably linked to the availability of NAD+, which is maintained by NAD+ salvage and lactate metabolism. Using lung t...

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Hlavní autoři:	Hayden T. Pacl, Krishna C. Chinta, Vineel P. Reddy, Sajid Nadeem, Ritesh R. Sevalkar, Kievershen Nargan, Kapongo Lumamba, Threnesan Naidoo, Joel N. Glasgow, Anupam Agarwal, Adrie J. C. Steyn
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Nature Portfolio 2023-09-01
Edice:	Nature Communications
On-line přístup:	https://doi.org/10.1038/s41467-023-40545-x
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