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PGM3 insufficiency: a glycosylation disorder causing a notable T cell defect

BackgroundHypomorphic mutations in the phosphoacetylglucosamine mutase 3 (PGM3) gene cause a glycosylation disorder that leads to immunodeficiency. It is often associated with recurrent infections and atopy. The exact etiology of this condition remains unclear.ObjectiveThis study aimed to characteri...

Täydet tiedot

Tallennettuna:
Päätekijät: Linlin Yang, Barbara Zerbato, Alex Pessina, Luca Brambilla, Virginia Andreani, Stefanie Frey-Jakobs, Manfred Fliegauf, Mohamed-Ridha Barbouche, Qiaoxia Zhang, Ferdinando Chiaradonna, Michele Proietti, Xin Du, Bodo Grimbacher
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Frontiers Media S.A. 2024-12-01
Sarja:Frontiers in Immunology
Aiheet:
PGM3 insufficiency
infections
CD4+ T cells
UDP-GlcNAc
glycosylation
Linkit:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1500381/full
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