Rich Organic Nitrogen Impacts Clavulanic Acid Biosynthesis through the Arginine Metabolic Pathway in Streptomyces clavuligerus F613-1

ABSTRACT Clavulanic acid (CA) is the preferred clinical drug for the treatment of infections by β-lactam antibiotic-resistant bacteria. CA is produced by Streptomyces clavuligerus, and although there have been many reports on the effects of carbon and nitrogen sources on CA production, the mechanism...

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Главные авторы:	Jiafang Fu, Xinru Xie, Shaowei Zhang, Ni Kang, Gongli Zong, Peipei Zhang, Guangxiang Cao
Формат:	Artigo
Язык:	Inglês
Опубликовано:	American Society for Microbiology 2023-02-01
Серии:	Microbiology Spectrum
Предметы:	clavulanic acid arginine metabolism metabolome transcriptome
Online-ссылка:	https://journals.asm.org/doi/10.1128/spectrum.02017-22
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