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Rich Organic Nitrogen Impacts Clavulanic Acid Biosynthesis through the Arginine Metabolic Pathway in Streptomyces clavuligerus F613-1

ABSTRACT Clavulanic acid (CA) is the preferred clinical drug for the treatment of infections by β-lactam antibiotic-resistant bacteria. CA is produced by Streptomyces clavuligerus, and although there have been many reports on the effects of carbon and nitrogen sources on CA production, the mechanism...

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Principais autores: Jiafang Fu, Xinru Xie, Shaowei Zhang, Ni Kang, Gongli Zong, Peipei Zhang, Guangxiang Cao
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2023-02-01
Serier:Microbiology Spectrum
Fag:
clavulanic acid
arginine metabolism
metabolome
transcriptome
Online adgang:https://journals.asm.org/doi/10.1128/spectrum.02017-22
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