The CagRS Two-Component System Regulates Clavulanic Acid Metabolism via Multiple Pathways in Streptomyces clavuligerus F613-1

Streptomyces clavuligerus F613-1 produces a clinically important β-lactamase inhibitor, clavulanic acid (CA). Although the biosynthesis pathway of CA has essentially been elucidated, the global regulatory mechanisms of CA biosynthesis remain unclear. The paired genes cagS and cagR, which are annotat...

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Autors principals:	Jiafang Fu, Ronghuo Qin, Gongli Zong, Cheng Liu, Ni Kang, Chuanqing Zhong, Guangxiang Cao
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2019-02-01
Col·lecció:	Frontiers in Microbiology
Matèries:	Streptomyces clavuligerus clavulanic acid CagRS arginine glyceraldehyde 3-phosphate primary metabolism
Accés en línia:	https://www.frontiersin.org/article/10.3389/fmicb.2019.00244/full
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