The CagRS Two-Component System Regulates Clavulanic Acid Metabolism via Multiple Pathways in Streptomyces clavuligerus F613-1

Streptomyces clavuligerus F613-1 produces a clinically important β-lactamase inhibitor, clavulanic acid (CA). Although the biosynthesis pathway of CA has essentially been elucidated, the global regulatory mechanisms of CA biosynthesis remain unclear. The paired genes cagS and cagR, which are annotat...

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Hlavní autoři:	Jiafang Fu, Ronghuo Qin, Gongli Zong, Cheng Liu, Ni Kang, Chuanqing Zhong, Guangxiang Cao
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2019-02-01
Edice:	Frontiers in Microbiology
Témata:	Streptomyces clavuligerus clavulanic acid CagRS arginine glyceraldehyde 3-phosphate primary metabolism
On-line přístup:	https://www.frontiersin.org/article/10.3389/fmicb.2019.00244/full
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