The CagRS Two-Component System Regulates Clavulanic Acid Metabolism via Multiple Pathways in Streptomyces clavuligerus F613-1

Streptomyces clavuligerus F613-1 produces a clinically important β-lactamase inhibitor, clavulanic acid (CA). Although the biosynthesis pathway of CA has essentially been elucidated, the global regulatory mechanisms of CA biosynthesis remain unclear. The paired genes cagS and cagR, which are annotat...

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Autori principali:	Jiafang Fu, Ronghuo Qin, Gongli Zong, Cheng Liu, Ni Kang, Chuanqing Zhong, Guangxiang Cao
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Frontiers Media S.A. 2019-02-01
Serie:	Frontiers in Microbiology
Soggetti:	Streptomyces clavuligerus clavulanic acid CagRS arginine glyceraldehyde 3-phosphate primary metabolism
Accesso online:	https://www.frontiersin.org/article/10.3389/fmicb.2019.00244/full
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