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Elamipretide (SS-31) improves mitochondrial dysfunction, synaptic and memory impairment induced by lipopolysaccharide in mice

Abstract Background It is widely accepted that mitochondria have a direct impact on neuronal function and survival. Oxidative stress caused by mitochondrial abnormalities play an important role in the pathophysiology of lipopolysaccharide (LPS)-induced memory impairment. Elamipretide (SS-31) is a no...

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Hlavní autoři: Weixing Zhao, Zhipeng Xu, Jiangbei Cao, Qiang Fu, Yishuang Wu, Xiaoying Zhang, Yue Long, Xuan Zhang, Yitian Yang, Yunfeng Li, Weidong Mi
Médium: Artigo
Jazyk:Inglês
Vydáno: BMC 2019-11-01
Edice:Journal of Neuroinflammation
Témata:
Elamipretide
SS-31
Antioxidant
Mitochondrial dysfunction
Oxidative stress
Neuroinflammation
On-line přístup:http://link.springer.com/article/10.1186/s12974-019-1627-9
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