An optimized protocol for expression and purification of monomeric full-length BAX protein for functional interrogations

Diverse developmental signals and pro-death stresses converge on the regulation of the mitochondrial pathway of apoptosis. BAX, a proapoptotic BCL-2 effector, directly forms proteolipid pores in the outer mitochondrial membrane to activate the mitochondrial pathway of apoptosis. BAX is a viable phar...

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Autori principali:	Yiyang Chen, Jesse D. Gelles, Jarvier N. Mohammed, Jerry Edward Chipuk
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Frontiers Media S.A. 2023-12-01
Serie:	Frontiers in Cell and Developmental Biology
Soggetti:	apoptosis BAX BCL-2 family mitochondria mitochondrial outer membrane permeabilization recombinant protein production
Accesso online:	https://www.frontiersin.org/articles/10.3389/fcell.2023.1322816/full
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