The unfolded protein response in fission yeast modulates stability of select mRNAs to maintain protein homeostasis

The unfolded protein response (UPR) monitors the protein folding capacity of the endoplasmic reticulum (ER). In all organisms analyzed to date, the UPR drives transcriptional programs that allow cells to cope with ER stress. The non-conventional splicing of Hac1 (yeasts) and XBP1 (metazoans) mRNA, e...

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Detalhes bibliográficos

Principais autores:	Philipp Kimmig, Marcy Diaz, Jiashun Zheng, Christopher C Williams, Alexander Lang, Tomas Aragón, Hao Li, Peter Walter
Formato:	Artigo
Idioma:	Inglês
Publicado em:	eLife Sciences Publications Ltd 2012-10-01
coleção:	eLife
Assuntos:	Unfolded Protein Response Ire1 selective mRNA decay Bip1 mRNA stabilization ER homeostasis
Acesso em linha:	https://elifesciences.org/articles/00048
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