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Transcriptional Modulation of Penicillin-Binding Protein 1b, Outer Membrane Protein P2 and Efflux Pump (AcrAB-TolC) during Heat Stress Is Correlated to Enhanced Bactericidal Action of Imipenem on Non-typeable Haemophilus influenzae

Objective: The purpose of the present study was to investigate the penicillin binding proteins (PBPs), drug influx and efflux modulations during heat stress and their effects on the bactericidal action of imipenem on non-typeable Haemophilus influenzae (NTHi).Methods: The two NTHi clinical isolates...

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Autori principali: Abdessalam Cherkaoui, Seydina M. Diene, Adrien Fischer, Stefano Leo, Patrice François, Jacques Schrenzel
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2018-01-01
Serie:Frontiers in Microbiology
Soggetti:
heat stress
NTHi
RNA-seq
AcrAB-TolC
OmpP2
PBP1b
Accesso online:http://journal.frontiersin.org/article/10.3389/fmicb.2017.02676/full
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