Robust activation of microhomology-mediated end joining for precision gene editing applications.

One key problem in precision genome editing is the unpredictable plurality of sequence outcomes at the site of targeted DNA double stranded breaks (DSBs). This is due to the typical activation of the versatile Non-homologous End Joining (NHEJ) pathway. Such unpredictability limits the utility of som...

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Detalhes bibliográficos

Principais autores:	Hirotaka Ata, Thomas L Ekstrom, Gabriel Martínez-Gálvez, Carla M Mann, Alexey V Dvornikov, Kyle J Schaefbauer, Alvin C Ma, Drena Dobbs, Karl J Clark, Stephen C Ekker
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Public Library of Science (PLoS) 2018-09-01
coleção:	PLoS Genetics
Acesso em linha:	https://doi.org/10.1371/journal.pgen.1007652
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