Robust activation of microhomology-mediated end joining for precision gene editing applications.

One key problem in precision genome editing is the unpredictable plurality of sequence outcomes at the site of targeted DNA double stranded breaks (DSBs). This is due to the typical activation of the versatile Non-homologous End Joining (NHEJ) pathway. Such unpredictability limits the utility of som...

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Библиографические подробности

Главные авторы:	Hirotaka Ata, Thomas L Ekstrom, Gabriel Martínez-Gálvez, Carla M Mann, Alexey V Dvornikov, Kyle J Schaefbauer, Alvin C Ma, Drena Dobbs, Karl J Clark, Stephen C Ekker
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Public Library of Science (PLoS) 2018-09-01
Серии:	PLoS Genetics
Online-ссылка:	https://doi.org/10.1371/journal.pgen.1007652
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