Spray-Dried Amorphous Solid Dispersions of Atorvastatin Calcium for Improved Supersaturation and Oral Bioavailability

Over the past few decades, the amorphous solid dispersions (ASDs) technique has emerged as a promising strategy to enhance the in vitro/in vivo characteristic of hydrophobic drugs. The low aqueous solubility and poor bioavailability of atorvastatin calcium (ATO), a lipid-lowering drug, present chall...

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Detalhes bibliográficos

Principais autores:	Jaewook Kwon, Bhupendra Raj Giri, Eon Soo Song, Jinju Bae, Junseong Lee, Dong Wuk Kim
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2019-09-01
coleção:	Pharmaceutics
Assuntos:	atorvastatin calcium hydroxypropyl methylcellulose (HPMC) amorphous solid dispersion spray-drying solubility enhancement bioavailability
Acesso em linha:	https://www.mdpi.com/1999-4923/11/9/461
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