Downstream Processing of Itraconazole:HPMCAS Amorphous Solid Dispersion: From Hot-Melt Extrudate to Tablet Using a Quality by Design Approach

The downstream processing of hot-melt extruded amorphous solid dispersions (ASDs) into tablets is challenging due to the low tabletability of milled ASDs. Typically, the extrudate strand is sized before milling, as the strand cannot be fed directly into the milling system. At the lab scale, the stra...

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Detalhes bibliográficos

Principais autores:	Saurabh M Mishra, Margarethe Richter, Luis Mejia, Andreas Sauer
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2022-07-01
coleção:	Pharmaceutics
Assuntos:	amorphous solid dispersion (ASD) hypromellose acetate succinate hot-melt extrusion (HME) downstream processing milling tablet compaction
Acesso em linha:	https://www.mdpi.com/1999-4923/14/7/1429
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