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A Simplified Liquid Chromatography-Mass Spectrometry Assay for Artesunate and Dihydroartemisinin, Its Metabolite, in Human Plasma

Artesunate (AS) is a potent antimalarial that is used worldwide for the treatment of malaria. A simple method with a total run time of 12 min was developed and validated for the quantification of AS and dihydroartemisinin (DHA), its active metabolite, in human (heparinized) plasma based on one-step...

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Tallennettuna:
Päätekijät: Victor Meléndez, Peter J. Weina, Mark M. Fukuda, Srisombat Wannaying, Robert S. Miller, David Saunders, Apassorn Lim, Nitima Chanarat, Roongnapa Apinan, Paktiya Teja-Isavadharm, Duangsuda Siriyanonda, Raveewan Siripokasupkul
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: MDPI AG 2010-12-01
Sarja:Molecules
Aiheet:
artesunate
dihydroartemisinin
human plasma
method validation
LC-MS
Linkit:http://www.mdpi.com/1420-3049/15/12/8747/
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