A Simplified Liquid Chromatography-Mass Spectrometry Assay for Artesunate and Dihydroartemisinin, Its Metabolite, in Human Plasma

Artesunate (AS) is a potent antimalarial that is used worldwide for the treatment of malaria. A simple method with a total run time of 12 min was developed and validated for the quantification of AS and dihydroartemisinin (DHA), its active metabolite, in human (heparinized) plasma based on one-step...

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Автори:	Victor Meléndez, Peter J. Weina, Mark M. Fukuda, Srisombat Wannaying, Robert S. Miller, David Saunders, Apassorn Lim, Nitima Chanarat, Roongnapa Apinan, Paktiya Teja-Isavadharm, Duangsuda Siriyanonda, Raveewan Siripokasupkul
Формат:	Artigo
Мова:	Inglês
Опубліковано:	MDPI AG 2010-12-01
Серія:	Molecules
Предмети:	artesunate dihydroartemisinin human plasma method validation LC-MS
Онлайн доступ:	http://www.mdpi.com/1420-3049/15/12/8747/
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