A gene-rich, transcriptionally active environment and the pre-deposition of repressive marks are predictive of susceptibility to KRAB/KAP1-mediated silencing

<p>Abstract</p> <p>Background</p> <p>KRAB-ZFPs (Krüppel-associated box domain-zinc finger proteins) are vertebrate-restricted transcriptional repressors encoded in the hundreds by the mouse and human genomes. They act via an essential cofactor, KAP1, which recruits effectors responsible for the form...

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Bibliografische gegevens

Hoofdauteurs:	Zangger Nadine, Quenneville Simon, Malani Nirav, Ambrosini Giovanna, Groner Anna C, Meylan Sylvain, Kapopoulou Adamandia, Kauzlaric Annamaria, Rougemont Jacques, Ciuffi Angela, Bushman Frederic D, Bucher Philipp, Trono Didier
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	BMC 2011-07-01
Reeks:	BMC Genomics
Onderwerpen:	KAP1 KRAB-zinc finger proteins transcriptional repression chromatin heterochromatin histone modifications
Online toegang:	http://www.biomedcentral.com/1471-2164/12/378
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