A gene-rich, transcriptionally active environment and the pre-deposition of repressive marks are predictive of susceptibility to KRAB/KAP1-mediated silencing

<p>Abstract</p> <p>Background</p> <p>KRAB-ZFPs (Krüppel-associated box domain-zinc finger proteins) are vertebrate-restricted transcriptional repressors encoded in the hundreds by the mouse and human genomes. They act via an essential cofactor, KAP1, which recruits effectors responsible for the form...

Täydet tiedot

Bibliografiset tiedot

Päätekijät:	Zangger Nadine, Quenneville Simon, Malani Nirav, Ambrosini Giovanna, Groner Anna C, Meylan Sylvain, Kapopoulou Adamandia, Kauzlaric Annamaria, Rougemont Jacques, Ciuffi Angela, Bushman Frederic D, Bucher Philipp, Trono Didier
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	BMC 2011-07-01
Sarja:	BMC Genomics
Aiheet:	KAP1 KRAB-zinc finger proteins transcriptional repression chromatin heterochromatin histone modifications
Linkit:	http://www.biomedcentral.com/1471-2164/12/378
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